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Image Search Results
Journal: The Journal of Biological Chemistry
Article Title: Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics
doi: 10.1074/jbc.M111.304485
Figure Lengend Snippet: Kinome tree depiction of the mTOR inhibitor off-targets in protein kinases. Figures were generated with DiscoveRx TREEspotTM Version 4. The original results were shown as percent control to DMSO, and targets exhibiting less than 1% remaining activity were selected in the figures. S score indicated the relative selectivity properties of the drugs with smaller S values signifying a more selective compound. The sizes of the red circle are proportional to the strength of the binding; the larger circles imply higher affinity.
Article Snippet: Figures were generated with
Techniques: Generated, Activity Assay, Binding Assay